Tigers 6, Astros 5 (11 innings)
DETROIT -- James McCann homered to lead off the bottom of the 11th inning and the Detroit Tigers, who squandered a five-run lead, pulled out a 6-5 victory over the Houston Astros on Thursday afternoon at Comerica Park.
The Tigers catcher hit an 0-2 pitch off Tony Sipp (2-1) for his first walkoff blast and his second home run of the season. Alex Wilson (1-0) pitched two innings of scoreless relief to get the victory.
Pinch-hitter Preston Tucker hit a one-out, opposite-field home run off Tigers closer Joakim Soria in the ninth to tie the score at 5. It was Tucker's first career homer and the Astros' major-league leading 62nd of the season.
Detroit starter David Price struck out a season-high 12 and held Houston scoreless until he allowed three runs -- two earned -- in the seventh. He had nine strikeouts on two occasions this year, including his most recent start against St. Louis on Saturday.
Tigers third baseman Nick Castellanos, who had a go-ahead, three-run triple against Milwaukee on Wednesday, hit his fourth homer of the season.
Detroit first baseman Miguel Cabrera collected his 1,400th career RBI and had two singles to extend his hitting streak to nine games. Left fielder Yoenis Cespedes added three hits and a walk while scoring twice for the Tigers (25-17).
Right fielder George Springer had two hits, scored a run and knocked in another for the American League West-leading Astros (27-15), who had won seven of their last eight before the four-game series opener.
Houston starting pitcher Scott Feldman gave up four earned runs in six innings.
A two-out walk to Cespedes got Feldman in trouble in the fourth. Castellanos followed with his two-run blast to left-center field.
The Tigers extended their lead to 4-0 in the fifth. Second baseman Ian Kinsler's fielder's choice groundout brought in a run after they loaded the bases with no outs. Cabrera followed with an RBI single.
Right fielder Rajai Davis made it 5-0 in the sixth with a run-scoring double.
Price was cruising until the seventh when the Astros suddenly erupted for three runs. Designated hitter Evan Gattis' triple brought in the first one and shortstop Jonathan Villar and catcher Hank Conger delivered two-out, RBI singles before Price was removed.
Springer's RBI double off Joba Chamberlain in the eighth made it 5-4.
NOTES: Tigers DH J.D. Martinez went 0-for-5, snapping his hitting streak at 11 games. ... Astros RF George Springer has walked 14 times in his last 15 games, including once on Thursday. ... Detroit won the season series 4-3 last year. ... The Tigers stole two bases and tied the Astros for the American League lead with 39. ... Astros RHP Josh Fields left the game after being struck on the leg by Detroit center fielder Anthony's Gose line single in the ninth inning.