Indians 6, White Sox 5 (10)
Carlos Santana's 10th-inning home run guided host Cleveland to its seventh straight victory.
After falling behind on Jeff Keppinger's pinch-hit, two-run single in the top of the ninth inning, Cleveland drew even in the bottom half on run-scoring sacrifice flies from Michael Bourn and Jason Kipnis. Santana ended things an inning later, drilling a 3-1 offering from Dylan Axelrod (3-7) over the right-field wall as the Indians extended their home winning streak to 10 games.
Chris Perez (4-1) earned the win with a perfect 10th inning as Cleveland improved to 10-2 against the White Sox this season and extended Chicago's losing streak to six games.
After Kipnis' RBI groundout opened the scoring in the first, Cleveland extended its lead in the fourth. Mike Aviles reached on a one-out single and came around to score on Michael Brantley's double to the warning track in straightaway center.
Santana's two-out RBI double made it a 3-0 game in the fifth, but the White Sox stormed back to tie in the sixth. Alexei Ramirez opened the rally with a run-scoring double, Alex Rios closed the gap with an RBI single and Adam Dunn capped the comeback with a single to shallow center.
GAME NOTEBOOK: Chicago starter Jose Quintana allowed three runs on seven hits while fanning six over five innings. Cleveland counterpart Corey Kluber threw a career-best 8 2/3 innings, allowing four runs on eight hits while striking out six. ... Quintana was originally scheduled to start Thursday's series finale but was moved up a day following Tuesday's trade that sent RHP Jake Peavy to the Boston Red Sox. ... Keppinger became the first Chicago pinch-hitter to drive in a run this season.